This article investigates the potential societal and spatial consequences of the recent pandemic. We present historical precedents, such as the bubonic plague or Black Death, and reflect upon contemporary writings on the ongoing global crisis. We argue that this crisis is not only a health crisis but an environmental and, more broadly, societal one. The article also focuses on the spatial implications of the worldwide lockdown that many cities in the world underwent and/or are undergoing. The historical lineage of modern workspaces is analyzed while arguing that lockdowns worldwide have rendered visible a radical mutation in the spatial organization of work in the 21st century. We suggest reading these structural and spatial mutations through concepts such as ‘immunity’ and ‘resilience.’ The article concludes that even though the impact of this crisis will be strong on society, the critical question we are all faced with today is “who the agent of that impact and consequently what its direction will be.”